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Studies on naphthyridines. Part 2. Synthesis of 4-substituted and 6-substituted 1,6-naphthyridin-5(6H)-ones

✍ Scribed by Mária Balogh; István Hermecz; Kálmán Simon; Levente Pusztay


Book ID
112129448
Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
554 KB
Volume
26
Category
Article
ISSN
0022-152X

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## Abstract Vilsmeier formylation of the 4‐amino‐2‐pyridinones 4a–d leads to the formation of the corresponding 3‐carbaldehydes 5a–d (the diformylated product 8 is isolated as a by‐product). A cyclizing Knoevenagel reaction of 5 with CH‐acidic nitriles 6 in the presence of piperidine gives substitu