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Conformationally Restrained Chiral PNA Conjugates: Synthesis and DNA Complementation Studies

โœ Scribed by Gangamani, B. P.; Decosta, M.; Kumar, V. A.; Ganesh, K. N.


Book ID
126696685
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
142 KB
Volume
18
Category
Article
ISSN
0732-8311

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A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH 2 ) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duple