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Chiral analogues of peptide nucleic acids: Synthesis of 4-aminoprolyl nucleic acids and DNA complementation studies using UV/CD spectroscopy

โœ Scribed by Bargur P. Gangamani; Vaijayanti A. Kumar; Krishna N. Ganesh


Book ID
108379157
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
898 KB
Volume
55
Category
Article
ISSN
0040-4020

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A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH 2 ) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duple