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Conformationally constrained tachykinins: N-methylated analogues of neurokinin A

โœ Scribed by P. Rovero; V. Pestellini; R. Patacchini; P. Santicioli; C. A. Maggi; A. Meli

Book ID
101719667
Publisher
Wiley (John Wiley & Sons)
Year
1989
Tongue
English
Weight
193 KB
Volume
28
Category
Article
ISSN
0006-3525

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โœฆ Synopsis

Limited conformational constraints have been introduced in the sequence of the C-terminal fragment of the peptide neurotransmitter neurokinin A by N-methylation of individual peptide bonds, and the biological activities of the peptides thus obtained were evaluated in order to assess the effect of such conformational constraint on receptor selectivity. The analogue methylated in position 7 shows enhanced selectivity toward NK-1 receptor.

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