Conformationally Constrained Analogues of Bleomycin A 5
β Scribed by Rishel, Michael J.; Thomas, Craig J.; Tao, Zhi-Fu; Vialas, Corine; Leitheiser, Christopher J.; Hecht, Sidney M.
- Book ID
- 127253123
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 287 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0002-7863
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Conformationally constrained spirofuropyridine analogues of epibatidine, syn-2 and anti-2, in which the 7-azabicyclo[2.2.1]heptane system and the 2-chloropyridine ring are held rigidly with the shorter and longer N-N distances, respectively, were synthesized from N-Boc-7-azabicyclo[2.2.1]heptan-2-on
Conformationally constrained analogues of (Z)-5-decenyl acetate (1), a pheromone component of the turnip moth, Agrotis segetum, have been synthesized and tested by using electrophysiological single-cell recordings. In the constrained analogues the terminal alkyl chain in 1 has been incorporated in a