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Conformational toolbox of oxazaborolidine catalysts in the enantioselective reduction of α-bromo-ketone for the synthesis of (R,R,)-formoterol

✍ Scribed by Robert Hett; Chris H. Senanayake; Stephen A. Wald

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
295 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Several conformationally constrained oxazaborolidine catalysts have been evaluated in the reduction of ketone 1. Readily accessible (1R, 2S ) l-amino-2 .tetralol (B-H) derived oxazaborolidine catalyst (6b) proves to be the most effective and practical catalyst in the reduction of bromo-ketone I (96% ee).

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