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Evaluating the role of solvent and borane on the enantioselectivity of the oxazaborolidine reduction of prochiral ketones using catalysts derived from cis-(1R,2S)-1-amino-indan-2-ol

✍ Scribed by Nathan J. Gilmore; Simon Jones

Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 102 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00401-4

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✦ Synopsis

The dependency of the enantioselectivity on the solvent and hydride source for the asymmetric reduction of acetophenone catalysed by the oxazaborolidine derived from cis-(1R,2S)-1-amino-indan-2-ol have been investigated. 11 B NMR studies have implied that monomer/dimer ratios are important for achieving high enantioselectivities.

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