Conformational modifications of cyclic hexapeptide somatostatin analogs
โ Scribed by Freidinger, Roger M. ;Perlow, Debra Schwenk ;Randall, William C. ;Saperstein, Richard ;Arison, Byron H. ;Veber, Daniel F.
- Book ID
- 115098152
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 424 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0367-8377
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We report the conformational analysis by 1 H-NMR in DMSO and computer simulations involving distance geometry and molecular dynamics simulations of peptoid analogs of the cyclic hexapeptide c-[Phe 11 -Pro 6 -Phe 7 -D-Trp 8 -Lys 9 -Thr 10 ] L-363,301 (the numbering refers to the positions in native s
The syntheses of new cyclic hexapeptides am described. These peptides potently displace [125a CGP-23996 (des-Alat, Glyz-d,samino-Cys~1Tyrt1]-dicarba %I4 SRIF) from SRlP receptors on AtT-20 cells. Two of these compounds are of potential value for the isolation of SRlF receptors by affiity chromatogra