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A super active cyclic hexapeptide analog of somatostatin

โœ Scribed by Daniel F. Veber; Richard Saperstein; Ruth F. Nutt; Roger M. Freidinger; Stephen F. Brady; Paul Curley; Debra S. Perlow; William J. Paleveda; C.Dylion Colton; Anthony G. Zacchei; Dominick J. Tocco; Dale R. Hoff; Richard L. Vandlen; John E. Gerich; Larry Hall; Lawrence Mandarino; Eugene H. Cordes; Paul S. Anderson; Ralph Hirschmann

Book ID
118942423
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
359 KB
Volume
34
Category
Article
ISSN
0024-3205

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We report the conformational analysis by 1 H-NMR in DMSO and computer simulations involving distance geometry and molecular dynamics simulations of peptoid analogs of the cyclic hexapeptide c-[Phe 11 -Pro 6 -Phe 7 -D-Trp 8 -Lys 9 -Thr 10 ] L-363,301 (the numbering refers to the positions in native s