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Conformational change in poly-L-lysine on reaction with polyacids

✍ Scribed by W. B. Gratzer; P. McPhie

Publisher
Wiley (John Wiley & Sons)
Year
1966
Tongue
English
Weight
380 KB
Volume
4
Category
Article
ISSN
0006-3525

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✦ Synopsis

When solutions of poly-lrlysine and poly(acry1ic acid) in salt solutions at neutral pH are mixed, complexes are formed. Optical rotatory dispersion studies of these complexes away from the equivalence point reveals the formation of a-helices. The a-helix content of the polylysine never rises above about 50%. On addition of 25% by volume of dioxane, the turbidity of the complex solutions disappears, and there is some enhance ment of the a-helix content. Poly(phosphoric acid) behaves essentially in the same way as poly(acry1ic acid). Poly(uridy1ic acid) forms complexes with polylysine but with no detectable formation of a-helix. The same is true of ribosomal RNA and native and denatured DNA. A number of other polyacid-polybase systems involving basic proteins have been examined, but again no a -h e h formation is induced. The results are related to the case of biological nucleoprotein complexes, and the conformational specificity of these systems is discussed. The effect of scattering on measured optical rotation has been investigated and is shown to be unimportant up to quite high levels.

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