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Conformational aspects of drug-DNA interactions: Studies on anthracycline antibiotics and psoralen derivatives

✍ Scribed by M. Palumbo; L. Capasso; G. Palù; S. Marcianimagno


Book ID
112828782
Publisher
Indian Academy of Sciences
Year
1985
Tongue
English
Weight
346 KB
Volume
8
Category
Article
ISSN
0250-5991

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The binding of the anthracyclines beta-rhodomycin-I and beta-rhodomycin-II to calf thymus DNA was investigated by both equilibrium and kinetic methods taking into account ligand dimerization (ionic strength I = 0.2 M, pH 6.0). The analysis was based upon a cooperative single-step binding mechanism w