Interaction of anthracycline antibiotics
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Dr. E. Stutter; Axel Walter; Werner F. Fleck
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Article
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1986
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John Wiley and Sons
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English
⚖ 805 KB
The binding of the anthracyclines beta-rhodomycin-I and beta-rhodomycin-II to calf thymus DNA was investigated by both equilibrium and kinetic methods taking into account ligand dimerization (ionic strength I = 0.2 M, pH 6.0). The analysis was based upon a cooperative single-step binding mechanism w