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Conformational analysis of a marine antineoplastic macrolide, bryostatin 10

โœ Scribed by Yoshiaki Kamano; Hui-ping Zhang; Hiroshi Morita; Hideji Itokawa; Osamu Shirota; George R. Pettit; Delbert L. Herald; Cherry L. Herald


Book ID
107857735
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
415 KB
Volume
52
Category
Article
ISSN
0040-4020

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An approach towards the C1โ€“C16 fragment
โœ J.S Yadav; A Bandyopadhyay; A.C Kunwar ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 134 KB

A stereo-and enantioselective approach towards the C 1 -C 16 fragment of bryostatins is reported using Jacobsen's catalyst for kinetic resolution of a terminal epoxide, a Horner-Wadsworth-Emmons coupling reaction and a 1,4-Michael type cyclization as key steps.