✦ LIBER ✦

An approach towards the C1–C16 fragment of antineoplastic macrolide bryostatins by kinetic resolution of a racemic terminal epoxide using Jacobsen's catalyst

✍ Scribed by J.S Yadav; A Bandyopadhyay; A.C Kunwar

Book ID: 104230906
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 134 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00841-3

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✦ Synopsis

A stereo-and enantioselective approach towards the C 1 -C 16 fragment of bryostatins is reported using Jacobsen's catalyst for kinetic resolution of a terminal epoxide, a Horner-Wadsworth-Emmons coupling reaction and a 1,4-Michael type cyclization as key steps.