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Conformation of pyridazine nucleosides: The molecular structure of 4-hydroxy-1-(β-d-ribofuranosyl)pyridazin-6-one (3-deaza-6-azauridine)

✍ Scribed by Bradford J. Graves; Derek J. Hodgson; David J. Katz; Dean S. Wise; Leroy B. Townsend

Book ID
115746842
Publisher
Elsevier Science
Year
1978
Weight
192 KB
Volume
520
Category
Article
ISSN
0005-2787

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The synthesis of 6-amino-4-methyl-8-(β-D
The synthesis of 6-amino-4-methyl-8-(β-D-ribofuranosyl) (4-H,8-H)pyrrolo-[4,3,2-de]pyrimido[4,5-c]pyridazine, a new tricyclic nucleoside
✍ Karl H. Schram; Leroy B. Townsend 📂 Article 📅 1971 🏛 Elsevier Science 🌐 French ⚖ 240 KB

We would like to report the synthesis of a derivative of the new heterocyclic ring system pyrrolo[4,3,2-de]pyrimido[4,5-clpyridazine. The reaction of 4-chloro-5-cyano-7-(g-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidine (I) (3) with methylhydrasine should have furnished 5-cyano-4-(N-l-methylhydrazino)-7-(B