Pyrrolopyridazine nucleosides. The synthesis of certain 1-β-D-ribofuranosyl-1H-pyrrolo[2,3-d]pyridazin-4(5H)-ones
✍ Scribed by Nabih S. Girgis; Roland K. Robins; Howard B. Cottam
- Book ID
- 112129826
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1990
- Tongue
- English
- Weight
- 227 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
We would like to report the synthesis of a derivative of the new heterocyclic ring system pyrrolo[4,3,2-de]pyrimido[4,5-clpyridazine. The reaction of 4-chloro-5-cyano-7-(g-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidine (I) (3) with methylhydrasine should have furnished 5-cyano-4-(N-l-methylhydrazino)-7-(B
Metallation of 5-ethynyl-1-(2,3,5-tri-O-terf-butyldimethylsilyl-~-~-ribof~anosyl)imidazole-4-carboxamide (1) using n-BuLi, deuteration with deuterium oxide and removal of the fertbutyldimethylsilyl protecting groups using tetrabutylammonium fluroide yielded [2-'H]-5ethynyl-1 -(~-D-ribofi1ranosyl)imi