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Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population

✍ Scribed by Parle-McDermott, Anne; Kirke, Peadar N; Mills, James L; Molloy, Anne M; Cox, Christopher; O'Leary, Valerie B; Pangilinan, Faith; Conley, Mary; Cleary, Laura; Brody, Lawrence C


Book ID
110026606
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
80 KB
Volume
14
Category
Article
ISSN
1018-4813

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## Abstract ## BACKGROUND A 28‐bp repeat polymorphism in the 5β€²UTR of the thymidylate synthase (__TYMS__) gene represents a candidate risk factor for neural tube defects (NTDs) due to involvement in folate‐dependent homocysteine metabolism. Non‐Hispanic, white, U.S. citizens carrying at least one