## Abstract ## BACKGROUND Fumonisin B1 (FB1) is a mycotoxin produced by the fungus __Fusarium verticillioides__, a common contaminant of corn worldwide. FB1 disrupts sphingolipid biosynthesis by inhibiting the enzyme ceramide synthase, resulting in an elevation of free sphingoid bases and depletio
Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy
โ Scribed by Claudia Kappen; Claudia Kruger; Jacalyn MacGowan; J. Michael Salbaum
- Book ID
- 113875783
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 701 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0890-6238
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## Abstract ## BACKGROUND Neural tube defects (NTDs) are congenital malformations arising mostly from incomplete neural tube closure during early embryogenesis. Most NTDs in humans have a complex etiology, with involvement of both genetic and environmental factors. More than 100 mouse models for h
Results from experimental animals and other laboratory data have suggested a role for methionine, an essential amino acid, in normal closure of the neural tube. We hypothesized that women who had higher dietary intakes of methionine would be at lower risk for neural tube defect (NTD)-affected pregna