The indolic ring system is quite activated towards electrophilic substitution but it also undergoes undesirable oxidations and oligomerizations readily. The nitration of indoles, even those substituted with withdrawing groups ~ such as -CN, COOR, NO2, COH2or COR, leads to poor yields of the desired
Configuration of 3-formyl-and 3-acetylindole and their N-methyl derivatives
β Scribed by S. V. Tsukerman; N. S. Pivnenko; A. I. Bugai; V. F. Lavrushin
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 1971
- Tongue
- English
- Weight
- 229 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0022-4766
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π SIMILAR VOLUMES
I3C chemical shifts are reported for a series of nitro and phenyl derivatives of 2-and 3-methylindoles and 2-and 3-formylindoles, measured in DMSO-d,. The I3C substituent chemical shift (SCS) data are discussed and compared with ' H SCS data.
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The syntheses and a preliminary pharmacological evaluation of some aminopropylindolizines and aminopropyltetrahydroindolizines are reported. All compounds showed anti-5-hydroxytryptamine, anti-histamine, and antiacetylcholine activities. Some also exhibited weak CNS activity.