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Regioselective nitration of 3-acetylindole and its N-acyl and N-sulfonyl derivatives

✍ Scribed by Olívia Ottoni; Rosimeire Cruz; Norbert H. Krammer

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
195 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The indolic ring system is quite activated towards electrophilic substitution but it also undergoes undesirable oxidations and oligomerizations readily. The nitration of indoles, even those substituted with withdrawing groups ~ such as -CN, COOR, NO2, COH2or COR, leads to poor yields of the desired nitro products, probably due to the undesirable reactions mentioned above.

Noland 3 reported the nitration of indoles substituted by withdrawing groups at the 2 and at the 3-

📜 SIMILAR VOLUMES

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✍ Rosimeire P. A. Cruz; Olivia Ottoni; Carlos A. M. Abella; Ligia B.. Aquino 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

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