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Conditionally replicative adenoviral vectors for malignant glioma

โœ Scribed by Adam M. Sonabend; Ilya V. Ulasov; Maciej S. Lesniak

Book ID
104590552
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
373 KB
Volume
16
Category
Article
ISSN
1052-9276

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โœฆ Synopsis

Abstract

Highโ€grade gliomas constitute an important challenge to modern medicine, and although great effort has been made to prolong patient survival, the prognosis for this disease remains poor. Due to recent discoveries in the molecular basis of gliomas, gene therapy is becoming a promising alternative. In this review, we discuss the use of conditionally replicative adenoviral vectors (CRAd) and their applications in neuroโ€oncology. Such vectors, when rendered conditionally replicative via transductional and transcriptional modifications, offer great promise for patients with malignant brain tumours. We review data from preclinical and clinical studies utilising such vectors and discuss the limitations and future perspectives of CRAd oncolytic therapy for malignant glioma. Copyright ยฉ 2006 John Wiley & Sons, Ltd.

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## Abstract ## Background Despite attempts to develop efficient viralโ€based gene transfer therapies for the treatment of malignant tumors, only limited progress has been made to improve the efficacy of this approach. As an alternative, the use of replicating oncolytic adenoviruses with and without