## Abstract Herpes simplex virus type 1 (HSVโ1) represents an attractive vehicle for a variety of gene therapy applications. To render this virus safe for clinical use, its cytotoxic genes must be removed without losing its ability to express transgenes efficiently. Our vectors are deleted for the
Multi-modal combination gene therapy for malignant glioma using replication-defective HSV vectors
โ Scribed by Edward A. Burton; Joseph C. Glorioso
- Book ID
- 114383463
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 179 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1359-6446
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ## Background Malignant glioma has a dismal prognosis. It was previously shown that glioma cells are efficiently killed when they express a gene coding for a hyperfusogenic mutant of the gibbon ape leukemia virus envelope glycoprotein (GALV.fus). However, production of viral vectors ex
Background The versatility of HSV-1 vectors includes large transgene capacity, selective replication of mutants in dividing cells, and availability of recombinant virus (RV) and plasmid-derived (amplicon) vectors, which can be propagated in a co-dependent, `piggyback', manner. Methods A replication