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Conditional Gene Inactivation Using cre Recombinase

✍ Scribed by E. Schipani

Book ID
105912994
Publisher
Springer
Year
2002
Tongue
English
Weight
113 KB
Volume
71
Category
Article
ISSN
1432-0827

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## Abstract Summary: Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Cre‐recombinase:__lox__P system used to create the mice allow