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Targeting and conditional inactivation of the murine Men1 locus using the Cre recombinase: loxP System

✍ Scribed by Christine Biondi; Michael Gartside; Ian Tonks; Carol Paterson; Nicholas K. Hayward; Graham F. Kay


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
202 KB
Volume
32
Category
Article
ISSN
1526-954X

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Inactivation of the murine Transferrin R
✍ Daniel F. Wallace; Ian D. Tonks; Anna Zournazi; Graham F. Kay; V. Nathan Subrama πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 139 KB πŸ‘ 1 views

## Abstract Summary: Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Cre‐recombinase:__lox__P system used to create the mice allow