Inactivation of the murine Transferrin R
β
Daniel F. Wallace; Ian D. Tonks; Anna Zournazi; Graham F. Kay; V. Nathan Subrama
π
Article
π
2004
π
John Wiley and Sons
π
English
β 139 KB
π 1 views
## Abstract Summary: Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Creβrecombinase:__lox__P system used to create the mice allow