Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: LoxP system

✍ Scribed by Daniel F. Wallace; Ian D. Tonks; Anna Zournazi; Graham F. Kay; V. Nathan Subramaniam

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 139 KB
• Volume: 39
• Category: Article
• ISSN: 1526-954X
• DOI: 10.1002/gene.20023

✦ Synopsis

Abstract

Summary: Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Cre‐recombinase:__lox__P system used to create the mice allows both full deletion and tissue‐specific deletion of TfR2. The development of these mice will provide new models for type 3 hemochromatosis and assist in determining the role of TfR2 in iron metabolism. genesis 39:38–41, 2004. © 2004 Wiley‐Liss, Inc.