Concise Synthesis of Novel Practical Sulfamide−Amine Alcohols for the Enantioselective Addition of Diethylzinc to Aldehydes
✍ Scribed by Mao, Jincheng; Wan, Boshun; Wang, Rongliang; Wu, Fan; Lu, Shiwei
- Book ID
- 111680701
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 217 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3263
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## Abstract Ephedrine‐derived sulfamide–amine alcohol **3** was found to be an effective catalyst for the asymmetric phenylacetylene addition to aldehydes at room temperature without using Ti(O^__i__^Pr)~4~ and Zn(OTf)~2~. It afforded the propargylic alcohols in high yields (up to 99%) and good ena
New nitrogen-containing ligands derived from the (1R,2R)-trans-cyclohexanediamine chiral core unit have been synthesized and fully characterized. Their catalytic activity was tested in the asymmetric addition of diethylzinc to aldehydes leading to the respective secondary alcohols with enantioselect