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Concise route to α-acylamino-β-keto amides: application to the synthesis of a simplified azinomycin A analogue

✍ Scribed by Jean-Yves Goujon; Michael Shipman


Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
158 KB
Volume
43
Category
Article
ISSN
0040-4039

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The Yoshimura intermediate in the total synthesis of bicyclomycin was prepared by intran~lecular addition of an amide to an ~ketoamide. The resulting unsymmetrical diketopiperazine was then converted to the diol-ether target.