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Concise route to the key intermediate for divergent synthesis of C7-substituted fluoroquinolone derivatives

โœ Scribed by Xin Zhang; Feng Mu; Bobby Robinson; Pengfei Wang

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
211 KB
Volume
51
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A concise route to ethyl 7-bromo-1-cyclopropyl-6,8-difluoro-4-quinolone-3-carboxylate has been developed. This compound is a key intermediate for divergent synthesis of various C7-substituted fluoroquinolones, a group of potent topoisomerase II inhibitors with promising clinical applications.

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