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Computational and Biological Evaluation of Quinazolinone Prodrug for Targeting Pancreatic Cancer

✍ Scribed by Pavel Pospisil; Houari Korideck; Ketai Wang; Yongliang Yang; Lakshmanan K. Iyer; Amin I. Kassis

Book ID
114853983
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
699 KB
Volume
79
Category
Article
ISSN
1747-0277

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## Abstract A severe limitation in cancer therapy is the often insufficient differentiation between malign and benign tissue using known chemotherapeutics. One approach to decrease side effects is antibody‐directed enzyme prodrug therapy (ADEPT). We have developed new glycosidic prodrugs such as (βˆ’