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Computation of the fraction of induced cells in enzyme induction systems

✍ Scribed by Urs Von Stockar; Ren Der Yang; Charles R. Wilke

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
522 KB
Volume
19
Category
Article
ISSN
0006-3592

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✦ Synopsis

Abstract

A theoretical model is developed for continuous multistage enzyme production systems, which consist of a growth fermentor used for growing microorganisms rapidly without enzyme production and a subsequent system of induction reactors in which enzymes induction and production occurs. The model allows the computation of the fraction of induced cells residing in the induction reactor for organisms exhibiting a lag phase in enzyme induction. For this model a general analytical solution was obtained for the cumulative internal residence time distribution of a series of n well‐stirred vessels with a recycle. The theoretical results are compared in a preliminary way with experimentally measured cellulase productivities of continuous multistage cellulose fermentations with Trichoderma viride QM 9414.

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