✦ LIBER ✦

Induction of differentiation in human myeloid leukemic cells by proteolytic enzymes

✍ Scribed by Eitan Fibach; Aliza Treves; Miriam Kidron; Michael Mayer

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 781 KB
Volume: 123
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041230212

No coin nor oath required. For personal study only.

✦ Synopsis

'Cells were cultured in the absence or presence of trypsin (40 pMj. NBT reduction was determined on day 4 and macrophages on days 10 and 14. AB, KS, and GM were patients were acute myeloid leukemia from whoin leukemia cells were isolated and cultured. ' < 5 % of the cells. :'>80% of the cells. 'Not determined.

📜 SIMILAR VOLUMES

Modulation of cell competence for induct

Modulation of cell competence for induction of differentiation in myeloid leukemic cells

✍ Geoff Symonds; Leo Sachs 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 778 KB

## Abstract It is shown that the competence of differentiation‐defective clones of mouse myeloid leukemic cells (MGI^−^D^−^ clones) to be induced for some differentiation‐associated properties can be modulated. For certain inducers this was effected by changing the type of serum and for another ind

Differentiation of human myeloid leukemi

Differentiation of human myeloid leukemic cells by phorbol esters: Correlation with tumor promotion

✍ Eitan Fibach; Israel Agranat; Eliezer A. Rachmilewitz 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 692 KB

The effect of the plant diterpenes, phorbol derivatives and mezerein, on differentiation of various human myeloid leukemic cells to macrophages was determined. The results indicate that, within the group of phorbol esters tested, a correlation exists between the potency of the compounds as inducers

Control of normal differentiation of mye

Control of normal differentiation of myeloid leukemic cells. IV. Induction of differentiation by serum from endotoxin treated mice

✍ Eitan Fibach; Leo Sachs 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 767 KB

## Abstract Sera from different strains of mice injected with endotoxin induced clones (D^+^) from a cultured line of myeloid leukemic cells to undergo normal differentiation to mature granulocytes and macrophages. Other clones (D^−^) derived from the same cell line were not inducible by these sera

Control of normal differentiation of mye

Control of normal differentiation of myeloid leukemic cells. XI. Induction of a specific requirement for cell viability and growth during the differentiation of myeloid leukemic cells

✍ Eitan Fibach; Leo Sachs 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

## Abstract Normal hematopoietic cells require the presence of a protein (MGI) in the appropriate conditioned medium (CM) for cell viability and growth and for differentiation to mature macrophages and granulocytes. Clones of myeloid leukemic cells have been established in culture (D^+^ clones) whi

Control of normal differentiation of mye

Control of normal differentiation of myeloid leukemic cells. VIII. Induction of differentiation to mature granulocytes in mass culture

✍ Eitan Fibach; Leo Sachs 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 741 KB

## Abstract There are three types of myeloid leukemic cells, IR^+^D^+^, IR^+^D^−^ and IR^−^D^−^. IR^+^D^+^ cells were induced to differentiate to granulocytes in mass culture in liquid medium by conditioned medium (CM) from cultures of lungs from mice injected with endotoxin. About 90% of the leuke

Control of in vivo differentiation of my

Control of in vivo differentiation of myeloid leukemic cells. iv. inhibition of leukemia development by myeloid differentiation-inducing protein

✍ Joseph Lotem; Leo Sachs 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 881 KB

## Abstract It is shown that a 5‐day schedule of two injections per day of the myeloid differentiation‐inducing protein MGI‐2 inhibited the __in vivo__ development of leukemia in SL and SJL/J mice with different syngeneic MGI^+^D^+^ clones of myeloid leukemic cells. With this schedule of treatment