## Abstract ^1^H NMR spectroscopic study of citalopram (CT) in the absence as well as in the presence of β‐cyclodextrin (β‐CD) in aqueous solution revealed the formation of four 1:1 β‐CD–CT inclusion complexes. The stoichiometry of the complexes was determined by the continuous variation (Job) meth
✦ LIBER ✦
Complexation of β-cyclodextrin with carborane derivatives in aqueous solution
✍ Scribed by Kiminori Ohta; Shunsuke Konno; Yasuyuki Endo
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 269 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
b-Cyclodextrin formed the most robust complexes with o-carboranols 1b and 1c in aqueous solution, and the association constants estimated from NMR titration studies indicated K a >1 Â 10 6 M À1 and K a = 6 Â 10 5 M À1 , respectively.
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## Abstract ^1^H NMR spectroscopic study of midazolam hydrochloride (MDL), β‐cyclodextrin (β‐CD) and their mixtures confirmed the formation of β‐CD‐MDL inclusion complex in aqueous solution. The stoichiometry of the complexes was determined by Scott's method to be 1:1, and the association constant