The nucleotide sequences that are important for transcription of the human thymidylate synthase gene were analyzed by deletion and site-directed mutagenesis of the promoter region. Deletion analyses from the 5ะ and 3ะ ends indicated the presence of multiple positive and negative elements. The promot
Complex Transcriptional Initiation Pattern of the Thymidylate Synthase Promoter in Mouse Tissues
โ Scribed by Yuandan Lee; Guohong Shen; Lee F. Johnson
- Book ID
- 115567932
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 110 KB
- Volume
- 372
- Category
- Article
- ISSN
- 0003-9861
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๐ SIMILAR VOLUMES
The mouse thymidylate synthase (TS) promoter is a member of a family of promoters that lack a TATA box as well as an initiator element and that initiate transcription at many sites over a broad initiation window. An element (MED-1) downstream of the initiation window of almost all promoters of this
## Abstract The promoter of the mouse thymidylate synthase (__TS__) gene lacks a TATAA box and an initiator element, is bidirectional and initiates transcription at multiple start sites across broad initiation windows upstream and downstream of the 30 nt essential promoter region. The TS promoter a