Analysis of Transcripts Derived from Sequences Upstream of the Bidirectional Mouse Thymidylate Synthase Promoter
β Scribed by Tina X. Lee; Lee F. Johnson
- Book ID
- 115602945
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 185 KB
- Volume
- 242
- Category
- Article
- ISSN
- 0014-4827
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The nucleotide sequences that are important for transcription of the human thymidylate synthase gene were analyzed by deletion and site-directed mutagenesis of the promoter region. Deletion analyses from the 5Π and 3Π ends indicated the presence of multiple positive and negative elements. The promot
The mouse thymidylate synthase (TS) promoter is a member of a family of promoters that lack a TATA box as well as an initiator element and that initiate transcription at many sites over a broad initiation window. An element (MED-1) downstream of the initiation window of almost all promoters of this