Complex karyotype with a masked Philadelphia translocation and variant BCR-ABL fusion in CML
โ Scribed by Sonal R. Bakshi; Beena P. Patel; Manisha M. Brahmbhatt; Pina J. Trivedi; Sarju B. Gajjar; Ramesh R. Iyer; Esha H. Parikh; Shilin N. Shukla; Pankaj M. Shah
- Book ID
- 113513469
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 188 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0165-4608
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๐ SIMILAR VOLUMES
A reciprocal translocation, t( I022)(q2Z;q I I), resulting in a masked Ph chromosome was identified in a patient diagnosed with chronic myeloid leukemia (CML). Both homologs of chromosome 9 were of the normal pattern. Two signals for the ABL probe, both of them hybridized to chromosome 9, were demon
W e performed molecular studies to resolve the status of BCR and ABL in the bone marrow cells of a CML patient with a Ph chromosome resulting from a complex translocation involving chromosomes 9, 15, and 22. D N A digestion with BomHI, Hindlll, and Bglll, followed by hybridization to a bcr-specific