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Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease

✍ Scribed by Russell H. Swerdlow; Bradley Weaver; Amy Grawey; Connie Wenger; Eric Freed; Bradford B. Worrall


Book ID
119302020
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
157 KB
Volume
247
Category
Article
ISSN
0022-510X

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## Abstract Alpha‐synuclein gene (__SNCA__) mutations cause familial Parkinsonism but the role of __SNCA__ variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of __SNCA__ genetic variation in 452 idiopathic PD cases and 245 controls. __SNCA__ copy numb