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Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

✍ Scribed by Alex Rajput; Carles Vilariño-Güell; Michele L. Rajput; Owen A. Ross; Alexandra I. Soto-Ortolaza; Sarah J. Lincoln; Stephanie A. Cobb; Michael G. Heckman; Matthew J. Farrer; Ali Rajput

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
369 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Alpha‐synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early‐onset disease in this population. The minor allele “G” at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression. © 2009 Movement Disorder Society

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