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Normal Mitochondrial Genome in Brain from Patients with Parkinson's Disease and Complex I Defect

✍ Scribed by P. Lestienne; J. Nelson; P. Riederer; K. Jellinger; H. Reichmann

Book ID
111175834
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
543 KB
Volume
55
Category
Article
ISSN
0022-3042

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Complex I Defect in muscle from patients
Complex I Defect in muscle from patients with Huntington's disease
✍ Dr JoaquΓ­n Arenas; Yolanda Campos; RenΓ© Ribacoba; Miguel A. MartΓ­n; Juan C. Rubi πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 439 KB πŸ‘ 2 views

We found a variable defect of complex I of the mitochondrial respiratory chain, ranging in severity from 25% to 63% of control values, in muscle of patients with Huntington's disease (HD). The most severe defect was observed in the patient with the greatest expansion of CAG triplets. Muscle morpholo