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Complex chromosomal rearrangements in patients with chronic myeloid leukemia

✍ Scribed by Libuse Babicka; Zuzana Zemanova; Lenka Pavlistova; Jana Brezinova; Sarka Ransdorfova; Lucie Houskova; Jana Moravcova; Hana Klamova; Kyra Michalova

Book ID
113512875
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
329 KB
Volume
168
Category
Article
ISSN
0165-4608

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Location of breakpoints within the major
Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes
✍ Dr. Ian DubΓ©; Julie Dixon; Teresa Beckett; Abraham Grossman; Martha Weinstein; P πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 460 KB

We report the sublocalization of the breakpoint in chromosome 22 in 33 patients with chronic myeloid leukemia (CML) who also had unusual marrow cytogenetics. In 23 patients, the leukemic clones were characterized by Philadelphia (Ph') chromosomes that arose through complex translocations that involv