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Complex Allylation by the Direct Cross-Coupling of Imines with Unactivated Allylic Alcohols

✍ Scribed by Masayuki Takahashi; Martin McLaughlin; Glenn C. Micalizio

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
408 KB
Volume
48
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

Regioselective, stereoselective: The convergent coupling of allylic alcohols with imines to deliver stereodefined homoallylic amines is described (see scheme). The process proceeds with net allylic transposition without the intermediacy of allylic organometallic reagents. Two stereodefined centers and a geometrically defined di‐ or trisubstituted alkene are forged with high selectivity.magnified image

📜 SIMILAR VOLUMES

ChemInform Abstract: Stereoselective Phe
ChemInform Abstract: Stereoselective Phenylation of Allylic Alcohol Derivatives by Palladium-Catalyzed Cross-Coupling with Hypervalent Silicon Complexes.
✍ M.-R. BRESCIA; P. DESHONG 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Stereoselective Phenylation of Allylic Alcohol Derivatives by Palladium-Catalyzed Cross-Coupling with Hypervalent Silicon Complexes. -The silicate complex (II) is found to be a highly effective reagent for the phenylation of allylic benzoates. The phenylation is completely stereoselective and occur