Complement regulatory proteins present on the surface of various mammalian cells play an important role in controlling homologous lysis, by interacting with C3 (and usually C4). These proteins have a similar structural motif ("short consensus repeat") (Reid, K.B.
Complement factor H and related proteins: an expanding family of complement-regulatory proteins?
โ Scribed by Peter F. Zipfel; Christine Skerka
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 695 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are constitutively expressed in human liver. I
The expression of the murine complement regulatory protein, Crry, in the CNS remains largely unexplored. In this study, we examined murine astrocytes and microglia purified from neonatal brain and sections of adult murine brain for the expression of Crry. Using RT-PCR, immunohistochemistry, in situ
## Abstract Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surface of activating substances. Using sulfated polyanions as model substances, an efficient fluidโpha