Complement C3b receptors on erythrocytes, circulating immune complexes, and complement C3 split products in patients with primary Sjögren's syndrome

✍ Scribed by Bjarne S. Thomsen; Peter Oxholm; Rolf Manthorpe; Henrik Nielsen

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 517 KB
• Volume: 29
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780290707

✦ Synopsis

Twenty-one patients with primary Sjogren's syndromie (SS) and 22 age-and sex-matched healthy controls were examined for levels of C3b receptors (CR1) on erythrocytes (by an enzyme-linked immunosorbent assay), levels of circulating immune complexes (IC) (by a polyethylene glycol precipitation complement consumptian method), and C3 split products, C3d and C3c (by intermediate gel rocket immunoelectrophoresis). CR1 varied within a wide range (2&124%), and a preponderalnce of low numbers was found among patients with primary SS (P < 0.05). The levels of circulating IC and C3d were elevated in primary SS patients (P < 0.01) and were mutually correlated (P < 0.01; T = O S ) , but levels of circulating IC and C3d did not correlate with CR1 values. C3c concentrations were the same in patients and controls. It is possible that the CR1 level serves as a predictor for the development of IC-induced manifestations, and the C3d concentration serves as an objective paralmeter for disease activity in primary SS.