Complement C3b receptors on erythrocytes in patients with juvenile rheumatoid arthritis

✍ Scribed by Bjarne S. Thomsen; Carsten Heilmann; Svend E. H. Jacobsen; Freddy K. Pedersen; Niels Morling; Bodil K. Jakobsen; Arne Svejgaard; Henrik Nielsen

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 489 KB
• Volume: 30
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780300902

✦ Synopsis

Forty patients with juvenile rheumatoid arthritis (JRA) were examined for C3b receptor (CRl) levels on erythrocytes (by an enzyme-linked immunosorbent assay), levels of circulating immune complexes (IC) (by a polyethylene glycol precipitation-complement consumption method), C3d split products (by intermediate gel rocket immunoelectrophoresis), and HLA-A, B, and C (by microdroplet lymphocytotoxicity test). Lower CRl levels were found predominantly among patients with JRA (mean 57%) compared with 40 age-matched controls (mean 68%) (P = 0.008). The CR1 levels differed when the JRA patients were grouped by mode of disease onset and by clinical state at the time of testing (levels in patients with pauciarticular disease were higher than those in patients with polyarticular disease, and levels in patients with polyarticular disease were higher than those in patients with systemic disease) or by sex (girls had higher levels than boys; P = 0.01). The levels of