Quantltation of serum complement components and plasma C3d in patients with malignant lymphoma: Relation to the stage of the tumor and circulating immune complexes
✍ Scribed by Hans Erik Heier; Tore Godal; Nicole A. Carpentier; Paul-Henri Lambert
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 495 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Total hemolytic complement activity (CH 50) and complement component levels were measured in 27 patients with Hodgkin's disease and 31 patients with non‐Hodgkin malignant lymphoma. CH 50 values were higher than normal in almost alt the patients. Increased levels of serum C4, C3 and factor B were observed in 62%, 31% and 19% of these patients, respectively. However, plasma concentration of C3d, a breakdown product of C3, was elevated in 29% of the cases. The hypercatabolism of C3 was nat closely associated with the presence of circulating immune complexes, as assessed by the Clq binding assay, nor with the presence of general symptoms in the patients. On the contrary, it appeared to be in relation with the extent of the malignant disease.