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Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders

✍ Scribed by Walz, C; Cross, N C P; Van Etten, R A; Reiter, A


Book ID
109886485
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
246 KB
Volume
22
Category
Article
ISSN
0887-6924

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Correlations of JAK2–V617F mutation with
✍ Matthaios Speletas; Eirini Katodritou; Chrisoula Daiou; Eudokia Mandala; Emmanou πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 212 KB

Recently, the acquired mutation JAK2-V617F has been described in the majority of patients with myeloproliferative disorders (MPDs). In this study we evaluated its clinical and laboratory correlates in 166 patients with MPDs. The mutation was detected by allele-specific PCR in 119 patients: 81.4% (35