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Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants

✍ Scribed by Diana Edo-Matas; Karel A. van Dort; Laurentia C. Setiawan; Hanneke Schuitemaker; Neeltje A. Kootstra


Book ID
113948258
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
651 KB
Volume
412
Category
Article
ISSN
0042-6822

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## Abstract A human CD4‐positive T cell line from a donor homozygous negative for the chemokine receptor CCR5 was established, characterized, and used for determining the coreceptor usage of human immunodeficiency virus type 1 (HIV‐1) isolates. Clones of this IL‐2 dependent human T‐cell lymphotropi