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Frequencies of SDF-1 chemokine, CCR-5, and CCR-2 chemokine receptor gene alleles conferring resistance to human immunodeficiency virus type 1 and AIDS in Kuwaitis

✍ Scribed by Voevodin, Alexander; Samilchuk, Elena; Dashti, Suhaila

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 159 KB
Volume: 58
Category: Article
ISSN: 0146-6615
DOI: 10.1002/(sici)1096-9071(199905)58:1<54::aid-jmv8>3.0.co;2-n

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✦ Synopsis

The frequencies of three mutations conferring resistance to HIV/AIDS were determined in a population sample of native Kuwaitis. The CCR2-64I, SDF1-3ЈA, and CCR5-m303 mutations were detected by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) tests using restriction endonucleases Bsa BI, Msp I, and Hinc II, respectively. The frequency of the mutant alleles were: for CCR2-64I, 0.1195 (95% CI 0.0801-0.1694); for SDF1-3ЈA, 0.2593 (95% CI 0.2024-0.3231), and for CCR5-m303, less than 0.0025. Thus, the CCR2-64I and especially SDF1-3ЈA mutations are sufficiently common in Arabs and can be used for prognostic genotyping in HIV-infected individuals from the Gulf countries.

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