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Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones

✍ Scribed by Kevin K. Ariën; Youssef Gali; Abdelkarim El-Abdellati; Leo Heyndrickx; Wouter Janssens; Guido Vanham


Book ID
113946686
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
655 KB
Volume
347
Category
Article
ISSN
0042-6822

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## Abstract A human CD4‐positive T cell line from a donor homozygous negative for the chemokine receptor CCR5 was established, characterized, and used for determining the coreceptor usage of human immunodeficiency virus type 1 (HIV‐1) isolates. Clones of this IL‐2 dependent human T‐cell lymphotropi