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Comparison of gastrointestinal absorption between human and rat: the role of intestinal absorptive surface area and unstirred aqueous layer

✍ Scribed by Ta C Wu; Chien Ma; Hyunyoung Jeong; Hsuan-Ming Yao; Win L Chiou


Book ID
117450045
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
60 KB
Volume
40
Category
Article
ISSN
0278-6915

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HT29-MTX and Caco-2/TC7 monolayers as pr
✍ Catherine Pontier; Jean Pachot; Roger Botham; Bernard Lenfant; Philippe Arnaud πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 410 KB

The permeability of 19 compounds in both the Caco-2/TC7 and HT29-MTX models was determined, and the ability of each model to predict intestinal absorption in humans was compared. Similar apparent permeability values (log P app ) were obtained in both models for the majority of compounds tested, and