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P44 Estimation of the unstirred water layer thickness in the human small intestine, and its importance in oral drug absorption

✍ Scribed by Fagerholm, U.; Lennernäs, H.

Book ID: 122385402
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 139 KB
Volume: 2
Category: Article
ISSN: 0928-0987
DOI: 10.1016/0928-0987(94)90217-8

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The presence of an aqueous diffusion layer or 'unstirred' water layer adjacent to the intestinal membrane has long been regarded as a potential barrier for intestinal absorption of compounds. Theoretical analyses were performed in the present study to quantitatively determine the effect of this laye