Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption

Effect of ‘unstirred’ water layer in the

Effect of ‘unstirred’ water layer in the intestine on the rate and extent of absorption after oral administration

✍ Win L. Chiou 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 476 KB 👁 2 views

The presence of an aqueous diffusion layer or 'unstirred' water layer adjacent to the intestinal membrane has long been regarded as a potential barrier for intestinal absorption of compounds. Theoretical analyses were performed in the present study to quantitatively determine the effect of this laye